Dermatologist Dr Dray on the safety of phenoxyethanol in skin care products. What is phenoxyethanol? Is phenoxyethanol safe in skin care and hair care? Should we avoid phenoxyethanol? #skincare #skincareingredients #skincarescience
0:00 Intro
0:16 What is phenoxyethanol
1:36 Carcinogen?
1:48 Reproductive harm?
2:06 Endocrine disruptor?
2:43 Neurologic problems?
6:25 Safety summary
7:10 Who should avoid phenoxyethanol?
7:49 Rant & ramble
?References
Puschmann J, Herbig ME, Muller‐Goymann CC. Correlation of antimicrobial effects of phenoxyethanol with its free concentration in the water phase of o/w‐emulsion gels. Eur J Pharm Biopharm 2018; 131: 152– 161.
CIR (Cosmetic Ingredient Review). Final report on the safety assessment of phenoxyethanol. J Am Coll Toxicol 1990; 9: 259– 278.
Wang Q, Cui S, Zhou L et al. Effect of cosmetic chemical preservatives on resident flora isolated from healthy facial skin. J Cosmet Dermatol 2019; 18: 652– 658.
Beene KM, Scheman A, Severson D, Reeder MJ. Prevalence of preservatives across all product types in the contact allergen management program. Dermatitis 2017; 28: 81– 87.
Pastor‐Nieto MA, Alcántara‐Nicolás F, Melgar‐Molero V et al. Preservatives in personal hygiene and cosmetic products, topical medications, and household cleaners in Spain. Actas Dermosifiliogr 2017; 108: 758– 770.
EPA U. United States Environmental Protection Agency. Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactivity, 2015. URL
Scortichini BH, Quast JF, Rao KS. Teratologic evaluation of 2‐phenoxyethanol in New Zealand White rabbits following dermal exposure. Fundam Appl Toxicol 1987; 8: 272– 279.
Hipwell AE, Kahn LG, Factor‐Litvak P et al. Exposure to non‐persistent chemicals in consumer products and fecundability: a systematic review. Hum Reprod Update 2019; 25: 51– 71.
Garlantézec R, Warembourg C, Monfort C et al. Urinary glycol ether metabolites in women and time to pregnancy: the PELAGIE cohort. Environ Health Perspect 2013; 121: 1167– 1173.
Warembourg C, Binter A‐C, Giton F et al. Prenatal exposure to glycol ethers and sex steroid hormones at birth. Environ Int 2018; 113: 66– 73.
Warembourg C, Botton J, Lelong N et al. Prenatal exposure to glycol ethers and cryptorchidism and hypospadias: a nested case‐control study. Occup Environ Med 2018; 75: 59– 65.
Morton WE. Occupational phenoxyethanol neurotoxicity: a report of three cases. J Occup Med 1990; 32: 42– 45.
Béranger R, Garlantézec R, Le Maner‐Idrissi G et al. Prenatal exposure to glycol ethers and neurocognitive abilities in 6‐year‐old children: the PELAGIE Cohort Study. Environ Health Perspect 2017; 125: 684– 690.
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